Authors
Ananya S Dewan, Mengmeng Li, Xiaobin Wang, Katherine Cameron
Published in
Placenta. Volume 186. Pages 216-222. Oct 22, 2026. Epub Oct 22, 2026.
Abstract
Hypertensive disorders of pregnancy (HDPs) are more common among women with uterine fibroids (UFs), although the role of micronutrients in this association is unclear. We examined associations of nutritional biomarkers with UFs and HDPs in a diverse cohort, and whether these biomarkers modified the association between UFs and HDPs.
This cross-sectional secondary analysis of the Boston Birth Cohort included patients with complete UF, HDP, maternal plasma folate and vitamin B12, and cord blood vitamin D data. Biomarkers were analyzed continuously and by quartiles. Logistic regression models evaluated interaction terms and joint exposures.
Of 722 participants, 87 (12%) had UFs, and 72 (10%) had HDP(s). Biomarkers did not differ by UF status. Compared with the highest quartile, the lowest folate quartile had higher HDP odds (OR 2.35; 95% CI 1.13-5.12; p for trend = 0.022), as did the highest homocysteine quartile compared with the lowest (OR 2.36, 95% CI 1.07-5.53, p for trend = 0.014). No biomarker × UF interactions were statistically significant. In joint-effects analyses, women with UFs and low folate had higher odds of HDPs than those without UFs and with adequate folate (OR 1.84, 95% CI 1.07-3.17).
Co-occurring UFs and low folate were associated with higher HDP odds, without evidence of effect modification. Because maternal blood samples were collected postpartum, we could not determine whether changes in folate levels preceded HDP onset. Prospective studies are needed to determine whether UF and folate status in early pregnancy could inform HDP risk assessment.
PMID:
42966348
Bibliographic data and abstract were imported from PubMed on 01 Nov 2026.
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